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GMP Recombinant Human IL-2 joins IL-7 and IL-15 produced within Bio-Techne’s dedicated animal-free GMP facility located in St. Paul MN USA. Our GMP-grade IL-2 contains the same cysteine to serine mutation found in Proleukin®. This mutation has been reported to prevent cysteine mispairing in E.coli, which can lead to protein aggregation and makes our new GMP-grade IL-2 protein soluble in injectable-grade water.

IL-2, IL-7, and IL-15 are critical cytokine components to many successful T and NK cell therapy programs.  Choosing these cytokines from a partner that can offer seamless translation from RUO to GMP means that the consistency across lots, the confidence in bioactivity, and cost-effectiveness are no longer barriers to manufacturing with consistency, translating with speed and scaling without limitation.  Learn more about these powerhouse cytokines in this brochure.

GMP-grade Recombinant Human IL-7 can now be produced at a game-changing scale within Bio-Techne’s new dedicated animal-free GMP facility. This flyer details manufacturing benefits and product specifications for GMP IL-7, including comparison to animal-free research-grade rhIL-7 to enable a seamless transition to GMP.

In this case study, ScaleReady helped an autologous T cell therapy company rapidly transition to a closed-system process for cell expansion by providing a testing plan to verify that G-Rex500M-CS closed-system bioreactors would meet their immediate cell production requirements and improve cell production efficiency, while adhering to their short timelines for going into clinical trials. In doing so, the company also uncovered small changes to their cell culture protocols that made a big impact on their cell production efficiency.

In this case study, a company requested help from ScaleReady to build business case for G-Rex®500M-CS bioreactors as the primary cell production platform for their autologous TCR T cell therapy pipeline. ScaleReady modeled operational costs for an autologous TCR T cell therapy company using G-Rex bioreactors. This provided transparency into long-term commercial viability of the ScaleReady platform.

In this case study, a company focused on autologous T cell therapies targeting solid tumor cancers was progressing into clinical trials and needed to transition from research-grade to GMP-grade cytokines. Concurrently they wanted to improve their methods of cytokine supplementation to reduce cytokine waste, improve dose accuracy across lots, and reduce process risk by defining methods for closed-system cytokine addition. ScaleReady detailed a plan to help them achieve these goals.

This video animation demonstrates a vision toward the industrialization and automation of T cell therapy manufacturing using G-Rex Bioreactors.

Video was created by Wilson Wolf Manufacturing Corporation.

In this brochure you will learn how G-Rex bioreactors solve the limitations of flask and bag-based cell therapy manufacturing. In this brochure:

• G-Rex Bioreactor mechanism of action
• Benefits for cell therapy manufacturing
• GatheRex Cell Harvest Pump
• User testimonials

In this video you will learn how G-Rex bioreactors solve the limitations of flask and bag-based cell therapy manufacturing. By providing cells with uninterrupted access to oxygen and nutrients, the G-Rex cell culture device is the only accessible cell expansion technology that linearly scales to meet the demands of cell therapy manufacturers.

This flyer provides details and data for our T cell and NK cell versions of ExCellerate media.